Press Release

MENLO PARK, Calif., Feb. 8, 2011 (GLOBE NEWSWIRE) -- Pacific Biosciences of California, Inc. (Nasdaq:PACB) will hold its quarterly conference call to discuss its Fourth Quarter 2010 results, Tuesday, February 15, at 4:30pm Eastern Time.

The call is being webcast by GlobeNewswire and can be accessed at Pacific Biosciences' website at: http://investor.pacificbiosciences.com/. 

Date: February 15, 2011

Time: 4:30pm ET

Listen via Internet: http://investor.pacificbiosciences.com/

Toll-free: 888.989.5214

International: 630.395.0127

Password: PACB

Replay: http://investor.pacificbiosciences.com/

About Pacific Biosciences

Pacific Biosciences' mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and proteins. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT™, technology. SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study.

CONTACT: Pacific Biosciences

         Trevin Rard

         650.521.8170

         ir@pacificbiosciences.com

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