Alliance panels include a 50-gene pharmacogenomics panel and a nearly 400-gene panel of challenging, medically relevant "dark genes" developed in collaboration with leading institutions
"Our customers have been asking for a way to focus their long-read experiments and maximize throughput," said
"These panels developed with PacBio enable customers to sequence regions of the genome that can help researchers study the role of genetics in drug response and uncover regions that are difficult to read, such as 'dark genes' and genes associated with neurodegenerative and cardiovascular diseases. Providing scientists with NGS tools enables them to further their research and gain a better understanding of the role that certain genes play in diseases, which could one day be translated to breakthroughs for patients," said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. "While these are long-read panels,
PacBio and Twist collaborated with researchers at leading institutions to develop two Alliance panels. One panel includes coverage of nearly 400 challenging medically relevant genes, and another was designed to capture 50 pharmacogenomic genes. Many of the challenging genes are in so-called "dark regions" of the human genome that are difficult to sequence or accurately map using standard short-read sequencing technologies. The dark gene panel was developed with researchers at a leading institution to interrogate and detect nearly 400 hard-to-sequence genes of medical significance, such as SMN1 and SMN2, GBA, and LPA, which are associated with Spinal Muscular Atrophy, Alzheimer's, and cardiovascular disease, respectively. The pharmacogenomics panel includes genes with high levels of evidence for implementation of prescribing guidelines.
In addition to the new capabilities provided by the long-read panels, PacBio is also collaborating with Twist to demonstrate the high level of accuracy that can be achieved using sequencing by binding (SBB) chemistry. By nature, SBB excels at correctly resolving homopolymer runs and repetitive regions. When applied to whole-exome sequencing, it has the potential to provide the most complete coverage of both uncomplicated and traditionally difficult to sequence genes which could streamline workflows by reducing the need for orthogonal assays.
In partnership with leading research institutions from around the world, Twist has curated a collection of high-quality target enrichment panels for applications ranging from carrier screening to cancer diagnostics and whole exome sequencing. The Twist Alliance Panels combine the strengths of precise, highly uniform oligonucleotide synthesis with the specialty expertise of leading scientific research partners.
Well designed, custom target enrichment panels enable increased sequencing depth on target genes while reducing overall sequencing. This allows for more sensitive detection of target sequences and higher confidence variant detection.
PacBio (NASDAQ: PACB) is a premier life science technology company that is designing, developing and manufacturing advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our products and technology under development stem from two highly differentiated core technologies focused on accuracy, quality and completeness which include our existing HiFi long read sequencing and our emerging SBB® short read sequencing technologies. Our products address solutions across a broad set of research applications including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications. For more information please visit www.pacb.com and follow @PacBio.
PacBio products are provided for Research Use Only. Not for use in diagnostic procedures.
Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by "writing" DNA on a silicon chip. Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries for drug discovery and development. Twist is also pursuing longer-term opportunities in digital data storage in DNA and biologics drug discovery. Twist makes products for use across many industries including healthcare, industrial chemicals, agriculture and academic research.
This press release contains "forward-looking statements" within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the
This press release contains forward-looking statements. All statements other than statements of historical facts contained herein, including without limitation, statements regarding the capability of the
For Twist Bioscience
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