MAS-Seq Supports Isoform Research Using Single-Cell RNA Sequencing from 10x Genomics
"We're thrilled to collaborate with these innovative organizations and bring new capabilities to our customers, enabling them to unlock new discoveries in their research," said
MAS-Seq will help single-cell researchers better identify and characterize novel isoforms, novel driver mutations, and cancer fusion genes, which are particularly relevant in the fields of cancer research and neurodegenerative diseases.
"Understanding cell heterogeneity at the isoform level is critical for basic and disease research," said
Together with the kit, PacBio will also release new SMRTLink software that supports single-cell transcriptome analysis, helping researchers easily glean insights from their data.
"The single cell revolution has already led to groundbreaking discoveries in biomedical research and has transformed our understanding of disease and development, yet there are so many more research questions and applications waiting to benefit from the power of single cell analysis," said
The MAS-Seq kit is the first in a series of products from PacBio to be included in its partnership with 10x Genomics as part of their Compatible Partner Program (CPP). The compatible partner program includes products that have been verified with 10x Genomics workflows.
"To date, we have had tremendous success using bulk Iso-Seq to facilitate the discovery of novel gene and isoform-resolved regulatory events pertaining to specific disease and developmental states. Today, we are excited to apply MAS-Seq technology to pioneer beyond tissue-specific associations and begin assigning these transcriptional features to specific cell populations. MAS-Seq data will ultimately better stratify disease-associated biology and enable more robust biomarker discovery for future functional validation from organism to tissue and now cell-specific outcomes," said
PacBio is now accepting orders for the MAS-Seq kit which will begin shipping in early November. PacBio will host a webinar on
Pacific Biosciences of California, Inc. (NASDAQ: PACB) is a premier life science technology company that is designing, developing and manufacturing advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our products and technology under development stem from two highly differentiated core technologies focused on accuracy, quality and completeness which include our existing HiFi long read sequencing and our emerging SBB™ short read sequencing technologies. Our products address solutions across a broad set of research applications including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications. For more information, please visit www.pacb.com and follow @PacBio.
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