UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date:	May 31, 2022

Accession Number:	0001104659-22-065260
Submission Type:	POS AM
CIK: 0001299130 Company Name: PACIFIC BIOSCIENCES OF CALIFORNIA, INC. File Number: 333-187363