Document And Entity Information [Abstract] Document Information [Table] Document Information [Line Items] Document Type Document Quarterly Report Current Fiscal Year End Date Document Period End Date Document Fiscal Year Focus Document Transition Report Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Shell Company Entity Common Stock Shares Outstanding Amendment Flag Entity Central Index Key Document Fiscal Period Focus Condensed Consolidated Balance Sheets [Abstract] Statement [Table] Statement [Line Items] Assets [Abstract] Assets Assets Current [Abstract] Current assets Cash And Cash Equivalents At Carrying Value Cash and cash equivalents at end of period Cash and cash equivalents Short Term Investments Investments Accounts Receivable Net Current Accounts receivable Inventory Net Inventory Inventory Prepaid Expense And Other Assets Current Prepaid expenses and other current assets Restricted Cash, Current Short-term restricted cash Assets Current Total current assets Property Plant And Equipment Net Property and equipment, net Operating Lease, Right-of-Use Asset Operating lease right-of-use assets, net Restricted Cash and Cash Equivalents, Noncurrent Long-term restricted cash Intangible assets, net Goodwill Goodwill, Ending Balance Goodwill, Beginning Balance Other Assets Noncurrent Other long-term assets Assets Total assets Liabilities and Stockholders’ Equity Liabilities Current [Abstract] Current liabilities Accounts Payable Current Accounts payable Accrued Liabilities, Current Accrued expenses Contract with Customer, Liability, Current Deferred revenue, current Operating Lease, Liability, Current Operating lease liabilities, current Other Liabilities Current Other liabilities, current Liabilities Current Total current liabilities Contract with Customer, Liability, Noncurrent Deferred revenue, non-current Contingent consideration liability, non-current Operating Lease, Liability, Noncurrent Operating lease liabilities, non-current Convertible Notes Payable, Noncurrent Convertible senior notes, net, non-current Other Liabilities, Noncurrent Other liabilities, non-current Liabilities Total liabilities Commitments and Contingencies Commitments and contingencies Stockholders Equity [Abstract] Stockholders' equity Preferred Stock Value Preferred stock, $0.001 par value: Authorized 50,000 shares; No shares issued or outstanding Common Stock, Value, Issued Common stock, $0.001 par value Authorized 1,000,000 shares; issued and outstanding 220,547 shares and 192,294 shares at September 30, 2021 and December 31, 2020, respectively Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated other comprehensive income Retained Earnings Accumulated Deficit Accumulated deficit Stockholders Equity Balance Balance Total stockholders' equity Liabilities And Stockholders Equity Total liabilities and stockholders' equity Preferred Stock Par Or Stated Value Per Share Preferred Stock, par value Preferred Stock Shares Authorized Preferred Stock, shares authorized Preferred Stock Shares Issued Preferred Stock, shares issued Preferred Stock Shares Outstanding Preferred Stock, shares outstanding Common Stock Par Or Stated Value Per Share Common Stock, par value Common Stock Shares Authorized Common Stock, shares authorized Common Stock Shares Issued Common Stock, shares issued Common Stock Shares Outstanding Balance, shares Balance, shares Common Stock, shares outstanding Condensed Consolidated Statements of Operations and Comprehensive Income (Loss) Product and Service [Axis] Products And Services [Domain] Product and Service [Domain] Product [Member] Product [Member] Service and Other [Member] Service And Other [Member] Service and Other [Member] Revenues [Abstract] Revenue: Revenues Total revenue Cost Of Revenue [Abstract] Cost of revenue: Cost of Goods and Services Sold Total cost of revenue Amortization of intangible assets Gross Profit Gross profit Operating Expenses [Abstract] Operating expense: Research And Development Expense Research and development Selling General And Administrative Expense Sales, general and administrative Merger-related expenses Acquisition-related costs Operating Expenses Total operating expense Operating Income Loss Operating loss Gain (Loss) on Contract Termination Loss (gain) from Continuation Advances Gain (loss) from Continuation Advances Interest Expense Interest expense Other Nonoperating Income Expense Other income (expense), net Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest Loss before benefit from income taxes Income Tax Expense (Benefit) Benefit from income taxes Net Income Loss Net Income loss Net income (loss) Net loss Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent [Abstract] Other comprehensive income (loss): Other Comprehensive Income Loss Available For Sale Securities Adjustment Net Of Tax Unrealized income (loss) on investments Other comprehensive income loss Comprehensive Income Net Of Tax Comprehensive income (loss) Earnings Per Share Basic And Diluted [Abstract] Net income (loss) per share: Earnings Per Share, Basic Net income (loss) per share, basic Basic Earnings Per Share, Diluted Diluted Weighted average shares outstanding used in computing net income (loss) per share Weighted Average Number of Shares Outstanding, Basic Weighted average shares used in computing net income (loss) per share, basic Basic Weighted Average Number of Shares Outstanding, Diluted Weighted average shares used in computing net income (loss) per share, diluted Diluted Condensed Consolidated Statement of Stockholders' Equity [Abstract] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common Stock [Member] Additional Paid In Capital [Member] Additional Paid-in Capital [Member] Accumulated Other Comprehensive Income [Member] Accumulated Other Comprehensive Income (Loss) [Member] Retained Earnings [Member] Accumulated Deficit [Member] Revision of Prior Period [Axis] Restatement [Domain] Revision of Prior Period [Domain] Revision Of Prior Period Accounting Standards Update Adjustment [Member] Revision of Prior Period, Accounting Standards Update, Adjustment [Member] Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Issuance of common stock in conjunction with equity plans Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Issuance of common stock in conjunction with equity plans, shares Value of stock issued in private placement net of issuance costs. Issuance of common stock in Private Placement, net of issuance costs Issuance of common stock in Private Placement, net of issuance costs, number of shares. Issuance of common stock in Private Placement, net of issuance costs shares Issuance of common stock in acquisition of Omniome Issuance of common stock in acquisition of Omniome, shares Issuance of common stock Stock Issued During Period, Value, New Issues Issuance of common stock from underwritten public equity offering, net of issuance costs Stock Issued During Period Shares New Issues Shares issued Issuance of common stock from underwritten public equity offering, net of issuance costs, shares Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation expense Condensed Consolidated Statements of Cash Flows [Abstract] Net Cash Provided By Used In Operating Activities [Abstract] Cash flows from operating activities Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Adjustments to reconcile net loss to net cash provided by (used in) operating activities Depreciation Depreciation The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) and research development expense in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method. Amortization of intangible assets and research development expense Amortization of intangible assets Amount of amortization expense attributable to right-of-use asset from operating lease. Operating Lease, Right-of-Use Asset, Amortization Amortization of operating lease right-of-use assets Amortization Of Financing Costs And Discounts Amortization of debt discount and financing costs Share Based Compensation Stock-based compensation Investment Income, Net, Amortization of Discount and Premium Amortization (accretion) from investment premium (discount) Deferred income taxes Increase Decrease In Operating Capital [Abstract] Changes in assets and liabilities Increase Decrease In Accounts Receivable Accounts receivable Increase Decrease In Inventories Inventory Increase Decrease In Prepaid Deferred Expense And Other Assets Prepaid expenses and other assets Increase Decrease In Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued expenses Increase (Decrease) in Deferred Service Revenue Deferred revenue Operating Lease, Payments Operating lease liabilities Increase Decrease In Other Current Liabilities Other liabilities Increase (Decrease) in Deferred Gain from Reverse Termination Fee Increase (Decrease) in Deferred Gain from Reverse Termination Fee Deferred gain from Reverse Termination fee Net Cash Provided By Used In Operating Activities Net cash provided by (used in) operating activities Net Cash Provided By Used In Investing Activities [Abstract] Cash flows from investing activities Payments To Acquire Property Plant And Equipment Purchase of property and equipment Cash paid for purchase of business acquisition, net of cash acquired Cash paid for purchase of business acquisition, net of cash acquired Payments To Acquire Investments Purchase of investments Proceeds From Sale Of Available For Sale Securities Sales of investments Proceeds From Maturities Prepayments And Calls Of Available For Sale Securities Maturities of investments Net Cash Provided By Used In Investing Activities Net cash used in investing activities Net Cash Provided By Used In Financing Activities [Abstract] Cash flows from financing activities Proceeds from (Repayments of) Contract Termination Proceeds from (Repayments of) Contract Termination Continuation Advances Repayments of Notes Payable Notes payable principal payoff Proceeds from Convertible Debt Proceeds from issuance of Convertible Senior Notes, net of issuance costs Estimated issuance costs Proceeds from issuance of common stock under equity offerings, net of issuance costs Proceeds from issuance of common stock under equity offerings, net of issuance costs. Proceeds from issuance of common stock under equity offerings, net of issuance costs Proceeds From Issuance Of Common Stock Proceeds from issuance of common stock from equity plans Proceeds from (Payments for) Other Financing Activities Other Net Cash Provided By Used In Financing Activities Net cash provided by financing activities Cash And Cash Equivalents Period Increase Decrease Net increase in cash and cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash and cash equivalents and restricted cash at end of period Cash and cash equivalents and restricted cash at beginning of period Restricted Cash and Cash Equivalents Restricted cash at end of period Supplemental disclosure of non-cash investing and financing activities Overview [Abstract] Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block] Overview Business acqusitions [Abstract] Business Combination Disclosure [Text Block] Business acquisitions Development and Commercialization Agreement [Abstract] Invitae Collaboration [Abstract] Development and Commercialization Agreement Disclosure [Text Block] Development and Commercialization Agreement Disclosure [Text Block] Invitae Collaboration Summary of Significant Accounting Policies [Abstract] Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Merger Termination [Abstract] Termination of Merger with Illumina [Abstract] Merger Termination Merger Termination Termination of Merger with Illumina Cash, Cash Equivalents and Investments [Abstract] Cash Cash Equivalents And Short Term Investments [Text Block] Cash, Cash Equivalents and Investments Supplemental Balance Sheet Components Disclosure [Abstract] Balance Sheet Components [Abstract] Supplemental Balance Sheet Disclosures [Text Block] Balance Sheet Components Commitments and Contingencies [Abstract] Loss Contingency Disclosures Commitments and Contingencies Convertible Senior Notes [Abstract] Debt Disclosure [Text Block] Convertible Senior Notes Stockholders' Equity [Abstract] Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Stockholders' Equity Revenue [Abstract] Revenue from Contract with Customer [Text Block] Revenue Basis Of Accounting Basis of Presentation and Consolidation Unusual or Infrequent Items, or Both, Disclosure [Text Block] COVID-19 Use Of Estimates Use of Estimates Fair Value Of Financial Instruments Policy Fair Value of Financial Instruments Earnings Per Share Policy [Text Block] Net Income (Loss) per Share Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration and Other Risks New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Schedule of Business Acquisitions, by Acquisition [Table] Business Acquisition [Line Items] Tabular disclosure of a material business combination completed during the period, details of total considerations transferred. Schedule of Business Acquisitions, by Acquisition Consideration Tranferred [Table Text Block] Schedule of Business Acquisitions, by Acquisition Consideration Tranferred Schedule of Business Acquisitions, by Acquisition Schedule of Unaudited Pro Forma Financial Information Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block] Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis Schedule Of Earnings Per Share Basic And Diluted Table [Text Block] Computation of Basic and Diluted Net Income (Loss) per Share Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Anti-dilutive Shares Excluded from Computation of Diluted Net Income (Loss) per Share Schedule Of Cash Cash Equivalents And Short Term Investments Table [Text Block] Summary of Cash, Cash Equivalents and Investments Marketable Securities [Text Block] Summary of Contractual Maturities of Cash Equivalents and Available-for-Sale Investments Schedule Of Inventory Current Table [Text Block] Components of Inventory Estimated Future Amortization Expense Of Acquisition-Related Intangible Assets With Definite Lives Changes to Goodwill Future Principal Payments , Fiscal Year Maturity Schedule of definite-lived intangible assets from business acquisitions Schedule of Long-term Debt Instruments [Table Text Block] Schedule of Net Carrying Amount Schedule of Interest Expense [Table Text Block] Schedule of Interest Expense [Table Text Block] Schedule of Interest Expense Lessee, Operating Lease, Description [Table Text Block] Lessee, Operating Lease, Description [Table Text Block] Schedule of Amount, Timing and Uncertainty of Cash Flows from Operating Leases Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Summary of Stock Option Activity Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block] Summary of Time-Based RSUs Activity Share-based Compensation, Performance Shares Award Nonvested Activity [Table Text Block] Summary of Performance-Based RSUs Activity Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block] Schedule of Stock-Based Compensation Expense Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block] Schedule of Fair Value of Employee Stock Options Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block] Schedule of Fair Value of Employee Stock Purchase Plan Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block] Schedule of Revenue by Geographic Location Summary of Revenue by Category [Table Text Block] Summary of Revenue by Category [Table Text Block] Summary of Revenue by Category Payments to Acquire Businesses, Gross Total cash paid Business Combination, Consideration Transferred, Equity Interests Issued and Issuable Fair value of share consideration Business Combination, Contingent Consideration, Liability Fair value of contingent consideration Contingent repayment liability Business Combination, Consideration Transferred Consideration Total consideration transferred Stock Issued During Period, Value, Stock Options Exercised Stock options issued by PacBio in replacement of Omniome’s unvested options Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles Allocation of purchase price to intangible assets Intangible assets, finite lived Price Per Share Allocated Share Based Compensation Expense Stock-based compensation expense Total stock-based compensation expense Income tax benefit from reduction in deferred tax assets valuation allowance. Income tax benefit from reduction in deferred tax assets valuation allowance Pro forma adjustment to reflect acquiree's acquisition-related costs. Pro forma adjustment related to acquiree's acquisition-related costs Business Combination, Pro Forma Information, Revenue of Acquiree since Acquisition Date, Actual Since the date of acquisition, revenues Business Combination, Pro Forma Information, Earnings or Loss of Acquiree since Acquisition Date, Actual Since the date of acquisition, net loss Finite-Lived Intangible Assets, Gross Gross Carrying Amount Business Combination, Consideration Transferred [Abstract] Stock-based compensation expense excluded from consideration transferred. Stock-based compensation expense excluded from consideration transferred Less: Stock-based compensation expense excluded from consideration transferred Major classes of assets and liabilities allocated to total fair value of consideration transferred Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents Cash and cash equivalents Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment Property and equipment, net The amount of property, operating lease right of use assets net recognized as of the acquisition date. Business Combination, Recognized Identifiable Assets Operating lease right-of-use assets, net Acquired and Liabilities Assumed Operating Lease Right of use assets Net Operating lease right-of-use assets, net Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Other Noncurrent Assets Other assets Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities Deferred income tax liability Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Liabilities Liabilities assumed Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net Total consideration transferred Business Acquisition, Pro Forma Information [Abstract] Business Acquisition, Pro Forma Revenue Pro forma total revenue Business Acquisition, Pro Forma Net Income (Loss) The pro forma basic and diluted net income per share for a period as if the business combination or combinations had been completed at the beginning of a period. Business Acquisition, Pro Forma Earnings Per Share, Basic and Diluted Pro forma net loss per sare - basic and diluted Schedule of Development and Commercialization Agreement Transactions [Table] Schedule of Development and Commercialization Agreement Transactions [Table] Development and Commercialization Agreement Transactions [Line Items] Development and Commercialization Agreement Transactions [Line Items] Development Program Term Development Program Term Development program term Preferential Pricing Period for each Program Product Preferential Pricing Period for each Program Product Preferential pricing period for each program product Merger Termination [Table] Merger Termination [Table] Debt Instrument [Axis] Debt Instrument Name [Domain] Debt Instrument, Name [Domain] Convertible Senior Notes [Member] Convertible Senior Notes [Member] Convertible Senior Notes [Member] Merger Termination [Line Items] Merger Termination [Line Items] Proceeds from Contract Termination Proceeds from Contract Termination Continuation Advances Continuation Advances Payable Per Agreement To Repay Advance If Change In Control Transaction Or Single Equity Or Debt Financing Takes Place Continuation Advances Payable Per Agreement To Repay Advance If Change In Control Transaction Or Single Equity Or Debt Financing Takes Place Possible Continuation Advances payable Merger Agreement, Period in Which Company must Repay Continuation Advances if Change-of-Control Transaction is Entered into with Third Party Merger Agreement, Period in Which Company must Repay Continuation Advances if Change-of-Control Transaction is Entered into with Third Party Period in which company must repay continuation advances if change-of-control transaction is entered into with third party Merger Agreement, Continuation Advances Repayable, Minimum Company must Raise in Equity or Debt Financing in a Single Transaction Merger Agreement, Continuation Advances Repayable, Minimum Company must Raise in Equity or Debt Financing in a Single Transaction Equity or debt financing that must be raised in a single transaction Debt Instrument Face Amount Principal amount of notes Debt Instrument Interest Rate Stated Percentage Debt instrument, stated interest rate Debt Instrument, Maturity Date Maturity date Repayments of Contract Termination Repayments of) Contract Termination Continuation Advances paid Proceeds from Fees Received Termination fee received Payments for Advisor Fees Payments for Advisor Fees Advisor fees paid Summary Of Significant Accounting Policies [Table] Summary Of Significant Accounting Policies [Table] Statistical Measurement [Axis] Range [Member] Range [Domain] Minimum [Member] Minimum [Member] Maximum [Member] Maximum [Member] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Sales Revenue Net [Member] Sales Revenue, Net [Member] Customer [Axis] Name Of Major Customer [Domain] Customer [Domain] Customer B [Member] Customer B [Member] Gene Company Limited [Member] Measurement Input Type [Axis] Measurement Input Type [Domain] Measurement Input Type [Domain] Measurement Input Discount Rate [Member] Measurement Input, Discount Rate [Member] Summary Of Significant Accounting Policies [Line Items] Summary Of Significant Accounting Policies [Line Items] Concentration Risk, Percentage Concentration risk, percentage Debt Instrument, Measurement Input Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Measurements Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value Inputs Level1 [Member] Level 1 [Member] Fair Value Inputs Level2 [Member] Level 2 [Member] Fair Value Inputs Level3 [Member] Level 3 [Member] Fair Value By Asset Class [Axis] Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain] Asset Class [Domain] Cash And Cash Equivalents [Member] Cash and cash equivalents [Member] Cash and money market funds. Cash And Money Market Funds [Member] Cash and money market funds [Member] Commercial Paper [Member] Commercial paper [Member] U S Government Corporations And Agencies Securities [Member] U.S. government and agency securities [Member] U S Treasury Securities [Member] U.S. Treasury security [Member] Investments [Member] Investments [Member] Commercial Paper Not Included With Cash And Cash Equivalents [Member] Commercial paper, not included with cash and cash equivalents [Member] Corporate Debt Securities [Member] Corporate debt securities [Member] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Cash And Cash Equivalents Fair Value Disclosure Total cash and cash equivalents Investments Fair Value Disclosure Total investments Short-Term Restricted Cash Fair Value Disclosure Short-Term Restricted Cash Fair Value Disclosure Short-term restricted cash: Cash Long-Term Restricted Cash Fair Value Disclosure Long Term Restricted Cash Fair Value Disclosure Long-term restricted cash: Cash Assets Fair Value Disclosure Total assets measured at fair value Liabilities [Abstract] Liabilities Contract Termination Contract Termination Continuation Advances Liabilities Fair Value Disclosure Total liabilities measured at fair value Earnings Per Share, Basic [Abstract] Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net income (loss) Earnings Per Share, Diluted [Abstract] Number of weighted averag stock options that have been outstanding to the total time in the period. Weighted average number of stock options Add: Weighted average stock options Weighted Average Number of Shares, Restricted Stock Add: Weighted average restricted stock units Weighted Average Number of Shares, Contingently Issuable Add: Weighted average shares issuable pursuant to ESPP Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities Name [Domain] Antidilutive Securities, Name [Domain] Employee Stock Option [Member] Options to purchase common stock [Member] Time-Based Restricted Stock Units (RSUs) [Member] Time Based Restricted Stock Units Rsus [Member] RSUs with time-based vesting [Member] Performance-Based Restricted Stock Units (RSUs) [Member] Performance Based Restricted Stock Units Rsus [Member] RSUs with performance-based vesting [Member] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] ESPP [Member] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Antidilutive securities excluded from the computation of earnings per share Schedule Of Available For Sale Securities [Table] Schedule of Available-for-sale Securities [Table] Financial Instrument [Axis] Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] Fair Value, Option, Eligible Item or Group [Domain] Cash, Cash Equivalents and Investments [Member] Cash Cash Equivalents And Investments [Member] Cash, cash equivalents and investments [Member] US Government Corporations and Agencies Securities, , Not Included with Cash and Cash Equivalents [Member] Us Government Corporations And Agencies Securities Not Included With Cash And Cash Equivalents [Member] U.S. government & agency securities, not included with cash and cash equivalents [Member] Long-Term Restricted Cash [Member] Long Term Restricted Cash [Member] Long-term restricted cash [Member] Schedule Of Available For Sale Securities [Line Items] Schedule of Available-for-sale Securities [Line Items] Available For Sale Securities Amortized Cost Amortized cost Amount of accumulated pre-tax unrealized gain before deducting pre-tax unrealized losses on investments in available-for-sale securities impacting investments. Available For Sale Securities Gross Unrealized Gain Accumulated In Investments Gross unrealized gains Amount of accumulated pre-tax unrealized loss before deducting pre-tax unrealized gain on investments in available-for-sale securities impacting investments. Available For Sale Securities Gross Unrealized Loss Accumulated In Investments Gross unrealized losses Available For Sale Securities Fair value Available-for-sale Securities, Debt Securities, Current Due in one year or less Available-for-sale Securities, Debt Securities, Noncurrent Due after one year through 5 years Available For Sale Securities Debt Securities Total investments Schedule of Balance Sheet Components [Table] Schedule of Balance Sheet Components [Table] Service [Member] Service [Member] Counterparty Name [Axis] Repurchase Agreement Counterparty Name [Domain] Counterparty Name [Domain] O’Brien Lease Agreement [Member] Obrien Lease Agreement [Member] O’Brien Lease Agreement [Member] Balance Sheet Components [Line Items] Balance Sheet Components [Line Items] Annual Decrease in Long-Term Restricted Cash Annual Decrease in Long-Term Restricted Cash May 1 annual decrease to long-term restricted cash Contract with Customer, Liability Deferred revenue Contract with Customer, Liability, Revenue Recognized Revenue recognized Contract with Customer, Liability, Noncurrent, Recognition Period Contract with Customer, Liability, Noncurrent, Recognition Period Deferred service revenue, noncurrent, recognition period Inventory Raw Materials Net Of Reserves Purchased materials Inventory Work In Process Net Of Reserves Work in process Inventory Finished Goods Net Of Reserves Finished goods Finite-Lived Intangible Assets [Line Items] Finite-Lived Intangible Assets, Accumulated Amortization Accumulated Amortization Finite-Lived Intangible Assets, Net Net Carrying Amount Finite-Lived Intangible Asset, Useful Life Estimated Useful Life (in years) Finite-Lived Intangible Asset, Expected Amortization, Remainder of Fiscal Year 2021 Finite-Lived Intangible Asset, Expected Amortization, Year One 2022 Finite-Lived Intangible Asset, Expected Amortization, Year Two 2023 Finite-Lived Intangible Asset, Expected Amortization, Year Three 2024 Finite-Lived Intangible Asset, Expected Amortization, Year Four 2025 Finite-Lived Intangible Asset, Expected Amortization, after Year Five 2026 and thereafter Schedule of Goodwill [Table] Goodwill [Line Items] Goodwill, Acquired During Period Long-term Debt, Fiscal Year Maturity [Abstract] Long-term Debt, Maturities, Repayments of Principal, Remainder of Fiscal Year Remainder of 2021 Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months 2022 Long-term Debt, Maturities, Repayments of Principal in Year Two 2023 Long-term Debt, Maturities, Repayments of Principal in Year Three 2024 Long-term Debt Net carrying amount Schedule of Long-term Debt Instruments [Table] Scenario [Axis] Scenario Unspecified [Domain] Scenario, Unspecified [Domain] Each Day During the First 180 Days [Member] Each Day During First180 Days [Member] Each Day During the First 180 Days [Member] One Hundred and Eighty-First Day to 360th Day [Member] One Hundred And Eighty First Day To360th Day [Member] 181st Day to 360th Day [Member] Debt Instrument [Line Items] Debt Instrument, Issuance Date Issuance date Debt Instrument, Conversion Rate, Shares Issued Per Stated Amount Debt Instrument, Conversion Rate, Shares Issued Per Stated Amount Shares issued conversion rate per $1,000 principal amount Debt Instrument, Stated Principal Amount for Conversion Rate Debt Instrument, Stated Principal Amount for Conversion Rate Principal amount for conversion rate Debt Instrument, Convertible, Conversion Price Conversion price per share Debt Instrument, Redemption Price, Percentage of Conversion Price Debt Instrument, Redemption Price, Percentage of Conversion Price Debt redemption, percentage of conversion price Debt Instrument, Redemption Price, Trading Days Debt Instrument, Redemption Price, Trading Days Debt redemption, trading days Debt Instrument, Redemption Price, Consecutive Trading Days Debt Instrument, Redemption Price, Consecutive Trading Days Debt redemption, consecutive trading days Debt Instrument, Redemption Price, Percentage Redemption price, percentage Debt Instrument, Additional Interest in the Event of Default Debt Instrument, Additional Interest in the Event of Default Additional interest in the event of default Debt Issuance Costs, Gross Debt issuance costs Debt Instrument, Interest Rate, Effective Percentage Debt instrument, effective interest rate Convertible Debt, Fair Value Disclosures Fair value of convertible debt Long-term Debt, Gross Principal amount Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Unamortized debt issuance costs Contractual Interest Expense Contractual Interest Expense Contractual interest expense Amortization of Debt Issuance Costs Amortization of debt issuance costs Interest Expense, Debt Total interest expense Commitments and Contingencies [Table] Commitments and Contingencies [Table] Litigation Case [Axis] Litigation Case Type [Domain] Litigation Case [Domain] PacBio IPR Petitions [Member] Pacbio Ipr Petitions [Member] PacBio IPR Petitions [Member] Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Operating Lease, Weighted Average Remaining Lease Term Weighted average remaining lease term Operating Lease, Weighted Average Discount Rate, Percent Weighted average discount rate Payments for Rent Rent payments Operating Lease, Cost Operating lease cost Number of Petitions Number of Petitions Number of petitions Additional Liability Associated With Indemnification Obligations Additional Liability Associated With Indemnification Obligations Additional liability associated with indemnification obligations Operating Lease, Liability Total operating lease liabilities Present value of operating lease liabilities Operating Lease Liabilities, Payments Due [Abstract] Maturity of Lease Liabilities Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year Remainder of 2021 Lessee, Operating Lease, Liability, Payments, Due Next Twelve Months 2022 Lessee, Operating Lease, Liability, Payments, Due Year Two 2023 Lessee, Operating Lease, Liability, Payments, Due Year Three 2024 Lessee, Operating Lease, Liability, Payments, Due Year Four 2025 Lessee, Operating Lease, Liability, Payments, Due after Year Five Thereafter Lessee, Operating Lease, Liability, Payments, Due Total undiscounted operating lease payments Lessee, Operating Lease, Liability, Undiscounted Excess Amount Less: imputed interest Balance Sheet Classification [Abstract] Balance Sheet Classification [Abstract] Balance Sheet Classification Stockholders' Equity [Table] Stockholders' Equity [Table] Award Type [Axis] Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Equity Award [Domain] Equity-Based Arrangements, Individual Contracts, Type of Deferred Compensation [Axis] Equity Based Arrangements Individual Contracts Type Of Deferred Compensation [Domain] Equity-Based Arrangements, Individual Contracts, Type of Deferred Compensation [Domain] Omniome Plan. Omniome Plan [Member] Omniome Plan [Member] 2020 Equity Incentive Plan [Member] Equity Incentive Plan2020 [Member] 2020 Equity Incentive Plan [Member] 2020 Inducement Equity Incentive Plan [Member] Inducement Equity Incentive Plan2020 [Member] 2020 Inducement Equity Incentive Plan [Member] Stockholders' Equity [Line Items] Stockholders' Equity [Line Items] The relative number of new shares that will be given to existing shareholders of a company that has been acquired or that has merged with another. Exchange ratio Share Based Compensation Arrangements By Share Based Payment Awards Number Of Active Plans Share Based Compensation Arrangements By Share Based Payment Awards Number Of Active Plans Number of equity compensation plans Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Shares authorized Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized Additional common stock reserved for issuance Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Common stock remain available for issuance Schedule Of Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Table] Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table] Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Axis] Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Domain] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain] Exercise price range one member. Exercise Price Range One [Member] $1.16 – 20.90 [Member] Exercise price range two member. Exercise Price Range Two [Member] $23.39 – 46.37 [Member] Exercise Price Range related to Omniome acqusition. Exercise Price Range Acqusition [Member] $2.05 – $4.90 [Member] Exercise Price Range Acqusition two. Exercise Price Range Acqusition Two [Member] $4.71 - $4.90 [Member] Exercise price range three member. Exercise Price Range Three [Member] $1.16 – 15.98 [Member] Exercise price range four member. Exercise Price Range Four [Member] $2.54 – 46.37 [Member] Exercise price range five member. Exercise Price Range Five [Member] $1.16 – 46.37 [Member] Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Number of shares, Outstanding at September 30, 2021 Number of shares, Outstanding at December 31, 2020 Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Number of shares, Granted Stock Issued During Period Shares Stock Options Exercised Number of shares, Exercised Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Number of shares, Canceled Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Lower Range Limit Exercise price, lower range Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Upper Range Limit Exercise price, upper range Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Weighted average exercise price, Outstanding at September 30, 21 Weighted average exercise price, Outstanding at December 31, 2020 Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price Weighted average exercise price, Granted Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price Weighted average exercise price, Exercised Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price Weighted average exercise price, Canceled Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Number of shares, Outstanding at September 30, 2021 Number of shares, Outstanding at December 31, 2020 Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Number of shares, Granted Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Number of shares, Released Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Number of shares, Forfeited Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Weighted average grant date fair value, Outstanding at September 30, 2021 Weighted average grant date fair value, Outstanding at December 31, 2020 Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted average grant date fair value, Granted Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Weighted average grant date fair value, Released Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Weighted average grant date fair value, Forfeited Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Merger-related expenses - cash-settled Merger Related Expenses Cash Settled [Member] Merger-related expenses - cash-settled [Member] Stock-based compensation. Stock Based Compensation [Member] Stock-based compensation [Member] Merger-related expenses - milestone. Merger Related Expenses Milestone [Member] Merger-related expenses - milestone [Member] Merger-related expenses - stock-settled. Merger Related Expenses Stock Settled [Member] Merger-related expenses - stock-settled [Member] Cost Of Sales [Member] Cost of revenue [Member] Research And Development Expense [Member] Research and development [Member] Selling General And Administrative Expenses [Member] Sales, general and administrative [Member] Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term 1 Expected term in years Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Volatility Rate Expected volatility Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Risk-free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Risk-free interest rate, minimum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Risk-free interest rate, maximum Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate Dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted average grant date fair value per share Schedule of Revenues from External Customers and Long-Lived Assets [Table] Geographical [Axis] Segment Geographical [Domain] Segment, Geographical [Domain] North America [Member] North America [Member] Europe [Member] Europe (including the Middle East and Africa) [Member] Asia Pacific [Member] Asia Pacific [Member] Revenues from External Customers and Long-Lived Assets [Line Items] Revenue from Contract with Customer, Excluding Assessed Tax Total revenue Schedule of Product Information [Table] Instrument [Member] Instrument [Member] Instrument [Member] Consumable [Member] Consumable [Member] Consumable [Member] Product Information [Line Items] Adjustments for New Accounting Pronouncements [Axis] Type Of Adoption [Member] Type of Adoption [Domain] Accounting Standards Update201904 [Member] Accounting Standards Update, Topic 326 [Member] Business Acquisition [Axis] Business Acquisition Acquiree [Domain] Business Acquisition, Acquiree [Domain] Circulomics Inc. (“Circulomics”), a Maryland-based biotechnology company focused on delivering highly differentiated sample preparation products that enable genomic workflows. Circulomics Inc [Member] Circulomics, Inc [Member] Omniome, Inc. (“Omniome”), a San Diego-based company developing a highly differentiated, proprietary short-read DNA sequencing platform capable of delivering high accuracy. Omniome Inc [Member] Omniome, Inc [Member] Time-based stock options. Time Based Stock Options [Member] Time-based stock options [Member] Performance Shares [Member] Performance-based stock options [Member] Indefinite-lived Intangible Assets [Axis] Indefinite Lived Intangible Assets Major Class Name [Domain] Indefinite-lived Intangible Assets, Major Class Name [Domain] In Process Research and Development, Intangible [Member] In Process Research And Development Intangible [Member] In Process Research and Development, Intangible [Member] Contingent Consideration by Type [Axis] Contingent Consideration Type [Domain] Contingent Consideration Type [Domain] Upon achievement of a milestone. Achievement Of Milestone [Member] Achievement of milestone [Member] Omniome stock awards in connection with the acquisition. Omniome Stock Awards Related To Acquisition [Member] Omniome stock awards related to acquisition [Member] Development Agreement [Member] Development Agreement [Member] Development Agreement [Member] Invitae Corporation [Member] Invitae Corporation [Member] Invitae Corporation [Member] Concentration Risk Type [Axis] Concentration Risk Type [Domain] Concentration Risk Type [Domain] Customer Concentration Risk [Member] Customer Concentration Risk [Member] Convertible Debt Securities [Member] Shares issuable upon conversion of convertible senior notes [Member] Short-Term Restricted Cash [Member] Short Term Restricted Cash [Member] Short-Term Restricted Cash [Member] Restricted Cash and Cash Equivalents [Axis] Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member] Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member] Customer Deposit [Member] Customer Deposit [Member] Customer Deposit [Member] Security Deposit [Member] Security Deposit [Member] Security Deposit [Member] Finite-Lived Intangible Assets by Major Class [Axis] Finite Lived Intangible Assets Major Class Name [Domain] Finite-Lived Intangible Assets, Major Class Name [Domain] Developed Technology Rights [Member] Developed Technology [Member] Customer Relationships [Member] Customer Relationships [Member]