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  <element id="pacb_UpfrontPayment" name="UpfrontPayment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="pacb_ExercisePriceRangeOneMember" name="ExercisePriceRangeOneMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="pacb_ExercisePriceRangeTwoMember" name="ExercisePriceRangeTwoMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="pacb_ExercisePriceRangeThreeMember" name="ExercisePriceRangeThreeMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="pacb_ExercisePriceRangeFourMember" name="ExercisePriceRangeFourMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="pacb_ExercisePriceRangeFiveMember" name="ExercisePriceRangeFiveMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="pacb_ProceedsFromIssuanceOfCommonStockNetOfIssuanceCosts" name="ProceedsFromIssuanceOfCommonStockNetOfIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="pacb_DeferredServiceRevenueCurrent" name="DeferredServiceRevenueCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="pacb_DeferredServiceRevenueNoncurrent" name="DeferredServiceRevenueNoncurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="pacb_DeferredContractualRevenueNoncurrent" name="DeferredContractualRevenueNoncurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="pacb_DeferredContractualRevenueCurrent" name="DeferredContractualRevenueCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="pacb_IncreaseDecreaseInDeferredServiceRevenue" name="IncreaseDecreaseInDeferredServiceRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="pacb_IncreaseDecreaseInDeferredContractualRevenue" name="IncreaseDecreaseInDeferredContractualRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="pacb_ContractualRevenue" name="ContractualRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="pacb_CommonStockCapitalSharesReservedForFutureIssuanceValue" name="CommonStockCapitalSharesReservedForFutureIssuanceValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="pacb_RevenueRecognitionMilestoneMethodRevenueMaximumRemainingToBeRecognized" name="RevenueRecognitionMilestoneMethodRevenueMaximumRemainingToBeRecognized" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="pacb_RevenueRecognitionMilestoneMethodRevenueMaximumToBeRecognized" name="RevenueRecognitionMilestoneMethodRevenueMaximumToBeRecognized" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
</schema>
