Press Release

MENLO PARK, Calif., Jan. 6, 2011 (GLOBE NEWSWIRE) -- Pacific Biosciences of California, Inc. (Nasdaq:PACB), developer of single molecule, real-time (SMRT™) technology for biological analysis, today announced that Hugh Martin, Chairman and CEO, will present an overview of the company at the 29^th annual J.P. Morgan Healthcare Conference in San Francisco on Tuesday, January 11 at 9:00 a.m. Pacific Standard Time. Mr. Martin's presentation will also be accessible via live webcast and archived http://investor.pacificbiosciences.com/events.cfm.

More information about Pacific Biosciences is available at www.pacificbiosciences.com.

About Pacific Biosciences

Pacific Biosciences' mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and proteins. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT™, technology. SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study.

CONTACT: Media:

         Nicole Litchfield

         For Pacific Biosciences

         415.793.6468

         nicole@bioscribe.com



         Investors:

         Trevin Rard

         Pacific Biosciences

         650.521.8450

         ir@pacificbiosciences.com

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